1) Drug development: Raise standards for preclinical cancer research
http://www.nature.com/nature/journal/v483/n7391/full/483531a.html2) Must try harder
http://www.nature.com/nature/journal/v483/n7391/full/483509a.html
It seems scientists are admitting that a lot of basic research on animals (preclinical studies) does not lead to benefits in clinical trials on humans (especially for cancer). Many causes are suggested, lack of reproducibility, bad stats, publication bias, etc. Only a few comments were made about the appropriateness of animal models.
From 1 above:
"Certainly, the limitations of preclinical tools such as inadequate cancer-cell-line and mouse models" (original source: & Nature Biotechnol. 28, 561–562 (2010)). Note that animals are labelled as tools.
A commentator said: "The claims presented here are pretty outlandish. Particularly relevant to "Hematology and Oncology" we now know that mice housed under different conditions with different microflora can have vastly different outcomes in any model, not just cancer."
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